Tyrosine hydroxylase: regulation by feedback inhibition and phosphorylation

Title: Tyrosine hydroxylase: regulation by feedback inhibition and phosphorylation
Creator: Dickson, Phillip W.; Briggs, Gabrielle D.
Relation: A New Era of Catecholamines in the Laboratory and Clinic p. 13-21
Relation: Advances in Pharmacology 68
Publisher Link: http://dx.doi.org/10.1016/B978-0-12-411512-5.00002-6
Publisher: Elsevier
Resource Type: book chapter
Date: 2013
Description: Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the biosynthesis of the catecholamines dopamine, noradrenaline, and adrenaline. In response to short-term stimuli, TH activity is regulated by feedback inhibition by the catecholamines and relief of that inhibition by phosphorylation. This chapter examines the current understanding of these regulatory mechanisms and the roles that they play in different catecholaminergic cells. This chapter also examines hierarchical phosphorylation in TH and how it provides a mechanism for the differential regulation of the major human TH isoforms.
Subject: tyrosine hydroxylase; feedback inhibition; phosphorylation; hierarchical; human; isoforms
Identifier: http://hdl.handle.net/1959.13/1066566
Identifier: uon:18174
Identifier: ISBN:9780124115125
Language: eng